A/Prof Lindy Jeffree
A/Prof R. L. (“Lindy”) Jeffree (BMedSci, MBBS, MSc, MHE, FRACS) is a full time public hospital neurosurgeon and former director of the Kenneth G. Jamieson Department of Neurosurgery, Associate Professor in the School of Medicine at the University of Queensland and Clinical Fellow at the QIMR Berghofer Medical Research Institute. She is a general neurosurgeon with particular expertise and interest in neuro-oncology, and a Part II examiner in Neurosurgery for Royal Australasian College of Surgeons.
Alongside her clinical load, A/Prof Jeffree has clinical and translational research collaborations in the fields of high-grade glioma, cerebral metastases, cerebral imaging and intensive care for neurotrauma. She has been working with the team at the Sid Faithful Brain Cancer Laboratory for more than ten years, with outcomes such the development of Q-cell, a panel of high quality, well characterised primary brain cancer cell line models for academia and commercial use.
Her research expertise is recognised by her involvement in national advisory committees for the Australian Brain Cancer Mission, the Mission for Traumatic Brain Injury Working Group on Acute Care, the Co-Operative trials Group in Neuro-Oncology (COGNO) and Brain Cancer Biobanking Australia (BCBA).
In addition to recruiting local patients and collecting clinical specimens, A/Prof Jeffree provides a neurosurgical and clinical perspective on all aspects of the research to ensure that projects are practically achievable and benefit patients.
Selected Publications
Colditz MJ, Jeffree RL. Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies. J Clin Neurosci. 2012 Nov;19(11):1471-4. doi: 10.1016/j.jocn.2012.03.009. Epub 2012 Sep 5. PMID: 22959448.
Colditz MJ, Leyen Kv, Jeffree RL. Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. J Clin Neurosci. 2012 Dec;19(12):1611-6. doi: 10.1016/j.jocn.2012.03.013. Epub 2012 Oct 9. PMID: 23059058.
Matsuyama M, Sachchithananthan M, Leonard R, Besser M, Nowak AK, Truran D, Vajdic CM, Zalcberg JR, Gan HK, Gedye C, Varikatt W, Koh ES, Kichenadasse G, Sim HW, Gottardo NG, Spyridopoulos D, Jeffree RL. What matters for people with brain cancer? Selecting clinical quality indicators for an Australian Brain Cancer Registry. Neurooncol Pract. 2021 Aug 31;9(1):68-78. doi: 10.1093/nop/npab055. PMID: 35096405; PMCID: PMC8789278.
Saunus JM, Quinn MC, Patch AM, Pearson JV, Bailey PJ, Nones K, McCart Reed AE, Miller D, Wilson PJ, Al-Ejeh F, Mariasegaram M, Lau Q, Withers T, Jeffree RL, Reid LE, Da Silva L, Matsika A, Niland CM, Cummings MC, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, Manning S, Nourse C, Nourbakhsh E, Wani S, Anderson MJ, Fink JL, Holmes O, Kazakoff S, Leonard C, Newell F, Taylor D, Waddell N, Wood S, Xu Q, Kassahn KS, Narayanan V, Taib NA, Teo SH, Chow YP, kConFab, Jat PS, Brandner S, Flanagan AM, Khanna KK, Chenevix-Trench G, Grimmond SM, Simpson PT, Waddell N, Lakhani SR. Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance. J Pathol. 2015 Nov;237(3):363-78. doi: 10.1002/path.4583. Epub 2015 Aug 19. PMID: 26172396.
Wann A, Tully PA, Barnes EH, Lwin Z, Jeffree RL, Drummond KJ, Gan H, Khasraw M. Outcomes after second surgery for recurrent glioblastoma: a retrospective case-control study. J Neurooncol. 2018 Apr;137(2):409-415. doi: 10.1007/s11060-017-2731-2. Epub 2018 Jan 2. PMID: 29294233
Jeffree RL, Stoodley MA. Postnatal development of arteriovenous malformations. Pediatr Neurosurg. 2009;45(4):296-304. doi: 10.1159/000235604. Epub 2009 Aug 19. PMID: 19690446.
Jeffree RL, Besser M. Colloid cyst of the third ventricle: a clinical review of 39 cases. J Clin Neurosci. 2001 Jul;8(4):328-31. doi: 10.1054/jocn.2000.0800. PMID: 11437572.
SLE Brownsett, K Ramajoo, D Copland, KL McMahon, G Robinson, Drummond K, RL Jeffree, S Olson, B Ong, De Zubicaray G. Language deficits following dominant hemisphere tumour resection are significantly underestimated by syndrome-based aphasia assessments. Aphasiology. 2019 May;33(10):1163-1181. https://doi.org/10.1080/02687038.2019.1614760
Jeffree RL. Current management of cerebral gliomas. Aust J Gen Pract. 2020 Apr;49(4):194-199. doi: 10.31128/AJGP-09-19-5063. PMID: 32233347.